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DeCS
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Descriptor English:
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Tumor Suppressor p53-Binding Protein 1
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Descriptor Spanish:
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Proteína 1 de Unión al Supresor Tumoral P53
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Descriptor Portuguese:
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Proteína 1 de Ligação à Proteína Supressora de Tumor p53
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Synonyms English:
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53BP1 Protein
TP53BP1 Protein
Tumor Protein p53 Binding Protein, 1
Tumor Protein p53-Binding Protein, 1
Tumor Suppressor p53 Binding Protein 1
p202 Protein
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Tree Number:
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D12.776.260.805
D12.776.660.235.850
D12.776.664.235.950
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Definition English:
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A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation. |
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History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56612
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Unique Identifier:
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D000071857
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Occurrence in VHL:
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Similar:
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DeCS
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